Pain sensitivity and clinical progression in Parkinson's disease
Identifieur interne : 000159 ( France/Analysis ); précédent : 000158; suivant : 000160Pain sensitivity and clinical progression in Parkinson's disease
Auteurs : Veit Mylius [Allemagne, France] ; Juliane Brebbermann [Allemagne] ; Helena Dohmann [Allemagne] ; Isabel Engau [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Jens C. Möller [Allemagne, Suisse, France]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Diagnosis, Disease Progression, Electric Stimulation, Electromyography, Female, Flexion reflex, Humans, Hyperalgesia (etiology), Male, Middle Aged, Nervous system diseases, Pain, Pain (etiology), Pain Measurement, Pain Threshold (physiology), Pain sensitivity, Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Perception, Questionnaires, Reflex (physiology), Somatosensory Disorders (etiology), Spinal Cord (physiopathology), clinical progression, early diagnosis, nociceptive flexion reflex, pain perception.
- MESH :
- complications : Parkinson Disease.
- etiology : Hyperalgesia, Pain, Somatosensory Disorders.
- physiology : Pain Threshold, Reflex.
- physiopathology : Spinal Cord.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Disease Progression, Electric Stimulation, Electromyography, Female, Humans, Male, Middle Aged, Pain Measurement, Questionnaires.
Abstract
Pain sensitivity in Parkinson's disease is known to be altered in an L‐dopa‐dependent manner with increased spinal nociception and experimental pain perception in the medication‐defined “off” state. As Parkinson's disease‐related pain can be an early symptom in Parkinson's disease, the present study aimed to investigate experimental pain sensitivity and spinal nociception during clinical progression. The nociceptive flexion reflex as a marker of spinal nociception as well as electrical and heat pain thresholds were assessed during the medication‐defined “off” state in 29 patients with Parkinson's disease divided into 3 severity groups (according to their Unified Parkinson's Disease Rating Scale motor score) and compared with 27 healthy elderly subjects. Parkinson's disease‐related pain was also quantified. Data provided evidence that spinal nociception and pain sensitivity are preserved during the early phase of Parkinson's disease. Following increased spinal nociception (F1,36 = 6.838, P = .013), experimental thermal and electrical pain sensitivity were augmented during the course of Parkinson's disease (F1,34 = 5.397, P = .014; F1,34 = 6.038, P = 0.053), whereas spinal nociception further increased (F1,34 = 5.397, P < .001). Increased experimental pain sensitivity was observed in patients exhibiting Parkinson's disease‐related pain. Spinal alterations either on the local level or induced by diminished dopaminergic descending inhibition probably led to increased pain sensitivity in later stages. Because Parkinson's disease‐related pain is correlated with experimental pain sensitivity these 2 observations likely reflect a causal relation. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23825
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2220">2220</biblScope><biblScope unit="page" to="2225">2225</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">04F3356567A0978BDB6F04D1A354DAE356BDB47D</idno><idno type="DOI">10.1002/mds.23825</idno><idno type="ArticleID">MDS23825</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Diagnosis</term><term>Disease Progression</term><term>Electric Stimulation</term><term>Electromyography</term><term>Female</term><term>Flexion reflex</term><term>Humans</term><term>Hyperalgesia (etiology)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Pain</term><term>Pain (etiology)</term><term>Pain Measurement</term><term>Pain Threshold (physiology)</term><term>Pain sensitivity</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Perception</term><term>Questionnaires</term><term>Reflex (physiology)</term><term>Somatosensory Disorders (etiology)</term><term>Spinal Cord (physiopathology)</term><term>clinical progression</term><term>early diagnosis</term><term>nociceptive flexion reflex</term><term>pain perception</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hyperalgesia</term><term>Pain</term><term>Somatosensory Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Pain Threshold</term><term>Reflex</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Disease Progression</term><term>Electric Stimulation</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Questionnaires</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Diagnostic</term><term>Douleur</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Perception</term><term>Réflexe flexion</term><term>Sensibilité douleur</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pain sensitivity in Parkinson's disease is known to be altered in an L‐dopa‐dependent manner with increased spinal nociception and experimental pain perception in the medication‐defined “off” state. As Parkinson's disease‐related pain can be an early symptom in Parkinson's disease, the present study aimed to investigate experimental pain sensitivity and spinal nociception during clinical progression. The nociceptive flexion reflex as a marker of spinal nociception as well as electrical and heat pain thresholds were assessed during the medication‐defined “off” state in 29 patients with Parkinson's disease divided into 3 severity groups (according to their Unified Parkinson's Disease Rating Scale motor score) and compared with 27 healthy elderly subjects. Parkinson's disease‐related pain was also quantified. Data provided evidence that spinal nociception and pain sensitivity are preserved during the early phase of Parkinson's disease. Following increased spinal nociception (F1,36 = 6.838, P = .013), experimental thermal and electrical pain sensitivity were augmented during the course of Parkinson's disease (F1,34 = 5.397, P = .014; F1,34 = 6.038, P = 0.053), whereas spinal nociception further increased (F1,34 = 5.397, P < .001). Increased experimental pain sensitivity was observed in patients exhibiting Parkinson's disease‐related pain. Spinal alterations either on the local level or induced by diminished dopaminergic descending inhibition probably led to increased pain sensitivity in later stages. Because Parkinson's disease‐related pain is correlated with experimental pain sensitivity these 2 observations likely reflect a causal relation. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Suisse</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Créteil</li><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Mylius, Veit" sort="Mylius, Veit" uniqKey="Mylius V" first="Veit" last="Mylius">Veit Mylius</name></region><name sortKey="Brebbermann, Juliane" sort="Brebbermann, Juliane" uniqKey="Brebbermann J" first="Juliane" last="Brebbermann">Juliane Brebbermann</name><name sortKey="Dohmann, Helena" sort="Dohmann, Helena" uniqKey="Dohmann H" first="Helena" last="Dohmann">Helena Dohmann</name><name sortKey="Engau, Isabel" sort="Engau, Isabel" uniqKey="Engau I" first="Isabel" last="Engau">Isabel Engau</name><name sortKey="Engau, Isabel" sort="Engau, Isabel" uniqKey="Engau I" first="Isabel" last="Engau">Isabel Engau</name><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C." last="Möller">Jens C. 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